M.D. Anderson's Office of Protocol Research defines new protocols to the system, enters the eligibility requirements and treatment plan, and enables patient registration once the protocol has completed the approval process successfully.

Investigators and research staff may register and randomize patients at their computer, with mandatory eligibility screening. The pharmacy consults computer registration records before dispensing investigational agents.

The IRB Continuing Review process is handled electronically through CORe. The document may be accessed and edited by the protocol's Principle Investigator (PI) or Manager. Once the document has been finalized the PI may sign and submit the form electronically to the IRB for review. Reports for current and archived Continuing Review forms are also available.